Vandyne High Priestess

From the Mighty Fountain of Life go one room east and two rooms south. Turn east five rooms and northwest one room. Go up and then one room southwest, and two more rooms east, then up again two rooms. You should be in an NPK room named "At The Peak". (You will need to be levitating to go further.) Search to reveal another exit up. Go up and then prepare yourself for CPK if you think anyone might try to PK you. Move northeast into the dizzy room and dispel it if you can either with dispel area, a negation orb, or something similar. Go one room west and after a few seconds you should be teleported to an NPK dizzy hallway. (This hallway can be tricky to navigate and very frustrating especially if someone is trying to chase you to PK.) Use the scan skill to determine how far you are from the eastern end of the hallway. Once you reach the east end of the hallway wait a few seconds and you should be teleported once again. You should find yourself in a room named "The Garden of Paradise". From here go two rooms southeast and you should find the High Priestess of Vandyne. (She is highly energy resistant and has the sanctuary spell affect so you will need to dispel her or you won't be able to get too many negative spells to land on her. Though it will be hard to dispel her it is possible. She's also immune to poison, but she can be weakened and cursed. Also note that because you won't be able to poison her she will regenerate fairly quickly outside of combat so it will be a little harder to solo her due to this.) She casts priest spells, tremor, blindness, plague, poison, etc. (*Note, that she can be webbed.) Once you are finished in the area you can recall or gohall from her room.

Vandyne Statue

From the Runic Temple recall in Rune:

1W, 2S

The easiest thing to do here is simply have an item that gives the passdoor spell. A druid's robe, or a mushroom from near Winterborn Mansion will do fine if you can't cast the spell in some form. Make sure that if you do use a mushroom that you have one for getting out also.

1E, 4Down

North in the NPK Entrance to the Crypts you should find the Vandyne Statue. (This statue uses Druid spells. She will web and blind you if she can see you.) The Druid smoke evocation or a flash bomb will be needed to blind the statue. Once she's blinded she's not too hard to kill even if you don't spell her up with any other negative spells. (If you use flash bombs to blind her that they won't be quite as effective as the smoke evocation spell.) Poison, plague, weaken, curse, faerie fire, and web her if you want to make the fight quicker. Once she dies you can loot the following possible items from her: a beautiful amulet made of white marble, a beautiful marble ring, a belt made of white marble, a bracelet made of marble, a bracer made of white marble, a mitre made of white marble, a pair of white marble gauntlets, a pair of white marble leg plates, a sheld made of white marble, a shimmering white cloak, a sword made of white marble, a white marble breastplate, an enchanted emerald scroll, and an orb of white marble.